What can cologuard detect? Cologuard is intended for the qualitative detection of colorectal neoplasia associated DNA markers and for the presence of occult hemoglobin in human stool. A positive result may indicate the presence of colorectal cancer (CRC) or advanced adenoma (AA) and should be followed by diagnostic colonoscopy., You can Find A Cancer Hospital Please Join Here, Please join All Cancer Treatment Centers, Be sure to consult your doctor, Health Guide