What does positive cologuard test mean? It means that Cologuard detected DNA and/or hemoglobin biomarkers in the stool which are associated with colon cancer or precancer. False positives and false negatives occur with Cologuard and appropriate follow-up is important. Patients with a positive result should have a diagnostic colonoscopy., You can Find A Cancer Hospital Please Join Here, Please join All Cancer Treatment Centers, Be sure to consult your doctor, Health Guide