Is a 3 cm colon polyp large? Definition of a Complex or Difficult Polypectomy - In general, sessile or pedunculated polyps more than 2 cm in diameter are considered difficult polyps. Certainly, any polyps greater than 3 cm in diameter, or so-called giant polyps, represent the most challenging polyps., You can Find A Cancer Hospital Please Join Here, Please join All Cancer Treatment Centers, Be sure to consult your doctor, Health Guide